Megakaryocyte development

Across TCGA patient cohorts, RNA activity of the Megakaryocyte development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, CNN1, and TGFB1I1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Megakaryocyte development activity versus SPARC in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+1.678	+0.892	<.001	<.001	3	8
OV	CNN1 →	+1.597	+0.887	<.001	<.001	3	8
OV	TGFB1I1 →	+1.347	+0.930	<.001	<.001	3	8
OV	CCN1 →	+2.002	+1.011	<.001	<.001	3	8
OV	COL8A1 →	+2.209	+0.833	<.001	<.001	3	8
OV	TAGLN →	+1.780	+0.998	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035855 vs SPARC — OV

Explore this scatter interactively →