Megakaryocyte development

Across TCGA cell cohorts, RNA activity of the Megakaryocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN1, TMEM184B, and CYP27B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCN1 grouped by Megakaryocyte development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCN1 →	-2.442	-0.984	<.001	<.001	3	5
STOMACH	TMEM184B →	-0.697	-1.394	<.001	<.001	3	5
BREAST	CYP27B1 →	+0.835	+0.731	.005	.006	1	6
KIDNEY	FAM53C →	-0.461	-0.946	.001	.004	2	5
KIDNEY	RTF1 →	-0.689	-0.997	.004	.008	2	5
KIDNEY	NF2 →	-0.872	-0.893	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCN1 by Megakaryocyte development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →