Megakaryocyte development

Across TCGA cell cohorts, RNA activity of the Megakaryocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, CAV1, and AJUBA, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Megakaryocyte development activity versus FLNA in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FLNA →	+2.751	+1.064	<.001	<.001	3	11
LARGE_INTESTINE	CAV1 →	+3.739	+0.890	<.001	.004	3	6
BREAST	AJUBA →	+1.290	+0.227	.002	.004	3	6
BREAST	CAVIN1 →	+2.938	+0.297	<.001	.005	3	6
OVARY	TICAM2 →	+1.272	+0.277	<.001	.002	3	5
OVARY	RND3 →	+2.281	+0.210	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035855 vs FLNA — BLOOD_Lymphoma

Explore this scatter interactively →