Epithelial cell differentiation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Epithelial cell differentiation involved in kidney development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, C8B, and COL3A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in kidney development activity versus TIMP2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMP2 →	+0.718	+0.083	<.001	<.001	3	9
BRCA	C8B →	+0.441	+0.033	<.001	<.001	3	9
CCRCC	COL3A1 →	+0.766	+0.048	<.001	.001	3	9
HNSC	CYGB →	+0.520	+0.052	<.001	.002	3	9
OV	LAMA4 →	+0.490	+0.046	.001	<.001	3	9
OV	NID2 →	+0.555	+0.059	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035850 vs TIMP2 — UCEC

Explore this scatter interactively →