Epithelial cell differentiation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Epithelial cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRN4CL, PMP22, and MYL9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in kidney development activity versus LRRN4CL in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRRN4CL →	+1.013	+0.337	<.001	.002	3	7
COAD	PMP22 →	+0.691	+0.351	<.001	.006	3	6
BRCA	MYL9 →	+0.925	+0.391	<.001	<.001	3	6
BRCA	FAM180A →	+0.781	+0.371	<.001	<.001	3	6
BRCA	ADGRL4 →	+0.755	+0.358	<.001	.002	3	6
BRCA	RASL12 →	+0.717	+0.462	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035850 vs LRRN4CL — BRCA

Explore this scatter interactively →