Epithelial cell differentiation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Epithelial cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, PODXL, and SRPX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in kidney development activity versus BASP1 in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BASP1 →	+3.729	+0.270	<.001	.003	3	8
BREAST	PODXL →	+2.574	+0.329	<.001	.006	3	7
OVARY	SRPX →	+2.135	+0.269	.005	.005	3	5
OVARY	MCCC2 →	-0.681	-0.277	.008	.006	3	5
OVARY	CLMP →	+2.380	+0.318	.004	<.001	3	5
OESOPHAGUS	MT2A →	+3.682	+0.426	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035850 vs BASP1 — BREAST

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