Homologous recombination

Across TCGA patient cohorts, RNA activity of the Homologous recombination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RFC1_T506, and RFC5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous recombination activity versus RFC1_S368 in LUAD (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_S368 →	+1.016	+0.087	<.001	<.001	3	10
LUAD	RFC1_T506 →	+1.255	+0.093	<.001	<.001	3	10
HNSC	RFC5 →	+0.445	+0.071	<.001	<.001	3	10
LSCC	RIF1 →	+0.510	+0.052	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.337	+0.087	<.001	<.001	3	10
LUAD	RRM2 →	+0.892	+0.087	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035825 vs RFC1_S368 — LUAD

Explore this scatter interactively →