Homologous recombination

Across TCGA cell cohorts, RNA activity of the Homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBAP2L, TMC7, and PRRC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous recombination activity versus UBAP2L in OVARY (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UBAP2L →	+0.655	+0.180	<.001	.002	3	4
LUNG_SCLC	TMC7 →	-0.584	-0.158	.002	.006	3	4
OESOPHAGUS	PRRC1 →	+0.738	+0.349	<.001	<.001	3	4
BLOOD_Lymphoma	GDF11 →	+0.831	+0.237	.008	<.001	2	5
BLOOD_Lymphoma	PM20D2 →	+1.085	+0.244	.001	<.001	3	4
BLOOD_Lymphoma	MRE11 →	+0.845	+0.339	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035825 vs UBAP2L — OVARY

Explore this scatter interactively →