Positive regulation of urine volume

Across TCGA cell cohorts, RNA activity of the Positive regulation of urine volume pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, HYAL2, and NPR1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDN1 grouped by Positive regulation of urine volume-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EDN1 →	-0.223	-0.709	<.001	.002	3	9
LUNG_NSCLC_LUAD	HYAL2 →	-0.203	-0.784	<.001	.001	2	8
KIDNEY	NPR1 →	-0.253	-1.127	.002	.001	2	7
STOMACH	ADORA2A →	-0.333	-1.288	.002	.004	3	6
CNS	HAS2 →	-0.208	-0.655	.002	.006	2	6
BLOOD_Myeloma	KAT14 →	-0.238	-1.140	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDN1 by Positive regulation of urine volume activity — PANCREAS

Explore this box plot interactively →