Positive regulation of urine volume

Across TCGA cell cohorts, RNA activity of the Positive regulation of urine volume pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRTFA, GADD45A, and MAP1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRTFA grouped by Positive regulation of urine volume-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRTFA →	+1.028	+1.466	.006	.001	2	6
LIVER	GADD45A →	+1.298	+1.739	.002	<.001	3	4
LIVER	MAP1B →	+3.045	+1.603	<.001	<.001	3	4
KIDNEY	NAV1 →	+1.922	+1.168	.008	.008	2	5
KIDNEY	SMPD4 →	+0.509	+0.920	.005	.003	3	4
CNS	CCDC88C →	-1.469	-0.888	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRTFA by Positive regulation of urine volume activity — SOFT_TISSUE

Explore this box plot interactively →