Positive regulation of mitochondrial membrane permeability

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF845, TMEM131L, and NAA16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF845 grouped by Positive regulation of mitochondrial membrane permeability-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF845 →	-0.841	-1.144	<.001	<.001	3	5
SOFT_TISSUE	TMEM131L →	-1.480	-1.458	.009	<.001	3	5
KIDNEY	NAA16 →	-1.003	-1.278	<.001	<.001	3	5
KIDNEY	MEF2A →	-0.963	-1.039	.001	.005	3	5
LUNG_SCLC	ZNF614 →	-1.368	-1.004	.001	.001	3	4
LUNG_SCLC	GARRE1 →	-0.580	-1.017	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF845 by Positive regulation of mitochondrial membrane permeability activity — LUNG_SCLC

Explore this box plot interactively →