Positive regulation of mitochondrial membrane permeability

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK1IP1L, CNOT7, and MT-ND3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial membrane permeability activity versus MAPK1IP1L in OVARY (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAPK1IP1L →	-0.923	-0.236	<.001	.002	3	4
OVARY	CNOT7 →	-0.887	-0.252	.001	.008	3	4
OVARY	MT-ND3 →	+1.086	+0.247	.001	.001	3	4
BLOOD_Myeloma	MRPS16 →	+0.661	+0.157	.002	.004	3	4
PANCREAS	SARNP →	-0.772	-0.222	.005	.001	3	4
LARGE_INTESTINE	ASCC3 →	-0.483	-0.203	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035794 vs MAPK1IP1L — OVARY

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