Cell migration involved in kidney development

pathway activity — cross-omics
GO:0035787Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell migration involved in kidney development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES_S768, NES, and CRMP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCANES_S768 →+0.609+0.067.002.00738
BRCANES →+0.440+0.078.004.00237
OVCRMP1 →+0.482+0.061.002.00136
OVDOCK1 →+0.353+0.096<.001<.00136
OVLAMA4 →+0.536+0.072.002.00636
LSCCFKBP9 →+0.467+0.121<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration