Cell migration involved in kidney development

pathway activity — cross-omics
GO:0035787Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell migration involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYDE1, PGAM1P8, and LRRC17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSYDE1 →+0.468+0.575<.001.00535
OVPGAM1P8 →-0.426-0.363.006.00234
BRCALRRC17 →+1.356+0.679.003.00134
CCRCCHSPA12B →+1.452+0.650<.001.00834
CCRCCDIPK2B →+1.215+0.634<.001.00234
CCRCCF2R →+1.014+0.672<.001.00334
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration