Endothelial cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Endothelial cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, DCN, and FBLN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell chemotaxis activity versus VCL_S795 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCL_S795 →	+0.584	+0.047	<.001	<.001	3	10
GBM	DCN →	+0.850	+0.084	<.001	<.001	3	10
OV	FBLN1 →	+0.792	+0.061	<.001	<.001	3	10
OV	LMCD1 →	+0.671	+0.064	<.001	.002	3	10
OV	EFEMP1 →	+1.159	+0.076	<.001	<.001	3	10
UCEC	RSU1 →	+0.437	+0.069	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035767 vs VCL_S795 — BRCA

Explore this scatter interactively →