Endothelial cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Endothelial cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AEBP1, COLEC12, and MSRB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell chemotaxis activity versus AEBP1 in PDAC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AEBP1 →	+0.947	+0.219	<.001	<.001	3	6
OV	COLEC12 →	+0.728	+0.095	.001	.002	3	6
LSCC	MSRB3 →	+0.706	+0.207	<.001	.003	3	6
LUAD	ITGA11 →	+0.945	+0.249	<.001	.008	3	5
LUAD	P4HA3 →	+0.451	+0.175	.007	.002	3	5
BRCA	VENTX →	+0.437	+0.242	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035767 vs AEBP1 — PDAC

Explore this scatter interactively →