Endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Endothelial cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBOF1, SNX16, and RPL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBOF1 grouped by Endothelial cell chemotaxis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BBOF1 →	-1.322	-1.508	.008	.006	3	5
LUNG_NSCLC_LUAD	SNX16 →	-0.578	-0.745	.006	.004	3	4
KIDNEY	RPL11 →	-0.720	-1.313	.008	.007	3	4
LUNG_NSCLC_LUAD	FMNL3 →	-1.121	-0.865	.002	.003	3	4
LUNG_NSCLC_LUAD	NPNT →	+1.657	+0.804	.007	.001	3	4
BREAST	RBM24 →	-1.903	-0.900	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBOF1 by Endothelial cell chemotaxis activity — BLOOD_Lymphoma

Explore this box plot interactively →