Endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Endothelial cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAD1, GPR34, and MYH13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATAD1 grouped by Endothelial cell chemotaxis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATAD1 →	+0.255	+0.238	.005	.005	3	5
LIVER	GPR34 →	-0.218	-0.304	.004	<.001	3	4
OESOPHAGUS	MYH13 →	+0.163	+0.179	.006	.002	3	4
LUNG_NSCLC_LUAD	ROPN1B →	+0.184	+0.161	.001	.002	3	4
LUNG_NSCLC_LUAD	FBLIM1 →	-0.143	-0.172	.002	.001	3	4
BLOOD_Leukemia	STMN3 →	-0.103	-0.229	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATAD1 by Endothelial cell chemotaxis activity — LIVER

Explore this box plot interactively →