Endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Endothelial cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1B, RAB13, and FIBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell chemotaxis activity versus CORO1B in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORO1B →	+1.065	+0.229	.002	.001	3	6
BREAST	RAB13 →	+0.830	+0.251	.002	.005	3	5
LUNG_NSCLC_LUAD	FIBP →	+0.593	+0.186	<.001	.007	3	5
BREAST	CFL1 →	+0.794	+0.240	.001	.001	3	4
LIVER	PIGQ →	+0.539	+0.190	.002	.006	3	4
KIDNEY	SPATA6 →	+1.299	+0.294	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035767 vs CORO1B — BREAST

Explore this scatter interactively →