B cell chemotaxis

Across TCGA patient cohorts, RNA activity of the B cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAT_S224, ICAM1, and VIM, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell chemotaxis activity versus LAT_S224 in OV (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAT_S224 →	+0.896	+0.085	<.001	<.001	3	10
GBM	ICAM1 →	+0.650	+0.100	<.001	<.001	3	9
LSCC	VIM →	+0.415	+0.102	<.001	<.001	3	8
GBM	CD4 →	+0.602	+0.132	<.001	<.001	3	8
GBM	DAB2 →	+0.728	+0.117	<.001	<.001	3	8
OV	DOCK11 →	+0.524	+0.070	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035754 vs LAT_S224 — OV

Explore this scatter interactively →