B cell chemotaxis

Across TCGA cell cohorts, RNA activity of the B cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XCL1, HSD3B7, and ARPP21, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XCL1 grouped by B cell chemotaxis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	XCL1 →	-0.453	-1.309	<.001	<.001	3	10
LARGE_INTESTINE	HSD3B7 →	-0.316	-1.403	.001	.008	3	8
CNS	ARPP21 →	-0.199	-1.329	<.001	<.001	3	4
BREAST	ANK2 →	-0.138	-1.079	<.001	<.001	3	3
LUNG_SCLC	ZNF354A →	-0.192	-0.851	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	NAT16 →	+0.186	+1.345	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XCL1 by B cell chemotaxis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →