B cell chemotaxis

Across TCGA cell cohorts, RNA activity of the B cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKB, APLP1, and RRM2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKB grouped by B cell chemotaxis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CKB →	+0.253	+0.817	.006	.008	3	5
LUNG_SCLC	APLP1 →	+0.187	+1.193	<.001	<.001	3	5
LUNG_SCLC	RRM2B →	-0.308	-1.278	<.001	<.001	3	5
LUNG_SCLC	STRN4 →	-0.293	-1.180	.001	<.001	3	4
URINARY_TRACT	PRDM1 →	-0.202	-1.768	.003	<.001	3	4
BONE	RNF141 →	-0.473	-1.339	.009	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKB by B cell chemotaxis activity — OVARY

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