Natural killer cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Natural killer cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKG7, SLC15A3, and IL12RB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell chemotaxis activity versus NKG7 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NKG7 →	+1.428	+0.948	<.001	<.001	3	9
GBM	SLC15A3 →	+0.874	+0.709	<.001	<.001	3	9
UCEC	IL12RB1 →	+0.836	+1.006	<.001	<.001	3	9
GBM	CYTH4 →	+1.076	+0.509	<.001	<.001	3	8
GBM	CD2 →	+1.406	+0.488	<.001	.003	3	8
HNSC	CD244 →	+0.851	+0.850	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035747 vs NKG7 — BRCA

Explore this scatter interactively →