Intraciliary transport involved in cilium assembly

Across TCGA patient cohorts, RNA activity of the Intraciliary transport involved in cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT74, ADNP, and CEP41, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary transport involved in cilium assembly activity versus IFT74 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IFT74 →	+0.537	+0.096	<.001	<.001	3	7
LSCC	ADNP →	+0.279	+0.059	.003	.001	3	6
OV	CEP41 →	+0.276	+0.056	.005	.002	3	6
LSCC	MSH6 →	+0.585	+0.063	<.001	.003	3	6
LUAD	RFC3 →	+0.233	+0.076	<.001	<.001	3	6
LSCC	HAUS1 →	+0.233	+0.059	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035735 vs IFT74 — GBM

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