Intraciliary transport involved in cilium assembly

Across TCGA patient cohorts, RNA activity of the Intraciliary transport involved in cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYND10, PCM1, and C9orf116, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary transport involved in cilium assembly activity versus ZMYND10 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZMYND10 →	+0.643	+0.419	.003	.001	3	7
BRCA	PCM1 →	+0.813	+0.456	<.001	<.001	3	6
BRCA	C9orf116 →	+1.063	+0.297	<.001	.002	3	6
LSCC	INTS9 →	+0.342	+0.529	<.001	.001	3	5
BRCA	VPS37A →	+0.454	+0.410	.001	<.001	3	5
HNSC	CNOT7 →	+0.486	+0.385	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035735 vs ZMYND10 — GBM

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