Common myeloid progenitor cell proliferation

Across TCGA cell cohorts, RNA activity of the Common myeloid progenitor cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAP1, CEACAM1, and FBXO4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAP1 grouped by Common myeloid progenitor cell proliferation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BAP1 →	-0.290	-1.431	<.001	<.001	3	11
LARGE_INTESTINE	CEACAM1 →	-0.263	-1.318	.001	.001	3	9
BREAST	FBXO4 →	-0.264	-1.008	<.001	<.001	3	6
LUNG_NSCLC_LUSC	ISCU →	+0.287	+1.487	.001	<.001	3	4
LUNG_NSCLC_LUSC	ABHD2 →	-0.286	-1.767	<.001	<.001	3	4
KIDNEY	TRIM72 →	+0.340	+1.442	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAP1 by Common myeloid progenitor cell proliferation activity — LARGE_INTESTINE

Explore this box plot interactively →