Common myeloid progenitor cell proliferation

Across TCGA cell cohorts, RNA activity of the Common myeloid progenitor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME7, TAGLN2, and MILR1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Common myeloid progenitor cell proliferation activity versus NME7 in SKIN (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NME7 →	-1.495	-0.306	.003	.001	3	2
SKIN	TAGLN2 →	-2.269	-0.309	<.001	.005	3	2
SKIN	MILR1 →	-3.003	-0.319	.005	.001	3	2
SKIN	SYNGR1 →	+1.830	+0.223	.006	.001	3	1
SKIN	SAMM50 →	+1.285	+0.223	.002	.002	3	1
SKIN	FKBP3 →	-0.661	-0.217	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035726 vs NME7 — SKIN

Explore this scatter interactively →