Sodium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Sodium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, SOD3, and C9orf40, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion transmembrane transport activity versus PIF1 in URINARY_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIF1 →	-1.568	-0.439	.005	.006	3	4
PANCREAS	SOD3 →	+1.106	+0.240	.001	<.001	3	4
PANCREAS	C9orf40 →	-0.880	-0.220	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	EIF3H →	-1.038	-0.400	.003	.004	3	4
PANCREAS	NUDT2 →	-1.109	-0.235	.001	.002	3	4
PANCREAS	RSBN1L →	-0.524	-0.209	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035725 vs PIF1 — URINARY_TRACT

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