Interleukin-12-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-12-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, SEMA4A, and VSIR_S235, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-12-mediated signaling pathway activity versus WAS in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WAS →	+0.511	+0.086	<.001	<.001	3	6
HNSC	SEMA4A →	+0.438	+0.078	<.001	<.001	3	5
LSCC	VSIR_S235 →	+0.448	+0.057	<.001	<.001	3	5
LSCC	CCDC88B →	+0.551	+0.091	<.001	<.001	3	5
LSCC	CSE1L →	-0.376	-0.088	<.001	<.001	3	5
HNSC	FGD3 →	+0.260	+0.061	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035722 vs WAS — HNSC

Explore this scatter interactively →