Interleukin-12-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-12-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAL1, CDK7, and NELFE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAL1 grouped by Interleukin-12-mediated signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNAL1 →	-0.801	-0.816	<.001	.007	3	5
BLOOD_Leukemia	CDK7 →	-0.587	-1.251	.005	.006	3	4
BREAST	NELFE →	-0.446	-0.746	.002	.001	3	3
LUNG_NSCLC_LUSC	TTLL3 →	-1.983	-1.571	.003	.002	2	4
URINARY_TRACT	SPRR1B →	-5.395	-1.663	<.001	.004	3	3
SOFT_TISSUE	CCDC28B →	+1.895	+1.613	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAL1 by Interleukin-12-mediated signaling pathway activity — BREAST

Explore this box plot interactively →