Intraciliary anterograde transport

Across TCGA patient cohorts, RNA activity of the Intraciliary anterograde transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT140, IFT74, and BBS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary anterograde transport activity versus IFT140 in UCEC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFT140 →	+0.369	+0.087	<.001	<.001	3	8
GBM	IFT74 →	+0.563	+0.082	<.001	<.001	3	8
UCEC	BBS2 →	+0.447	+0.086	<.001	<.001	3	7
LSCC	WDR19 →	+0.434	+0.075	<.001	<.001	3	7
UCEC	WDR54 →	+0.516	+0.083	<.001	<.001	3	7
OV	CETN2 →	+0.437	+0.047	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035720 vs IFT140 — UCEC

Explore this scatter interactively →