Intraciliary anterograde transport

Across TCGA patient cohorts, RNA activity of the Intraciliary anterograde transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPHP1, IQUB, and C9orf116, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary anterograde transport activity versus NPHP1 in LSCC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NPHP1 →	+0.453	+1.225	<.001	<.001	3	7
BRCA	IQUB →	+0.471	+0.415	<.001	<.001	3	6
BRCA	C9orf116 →	+0.873	+0.229	<.001	.004	3	6
LSCC	SPEF1 →	+0.490	+0.891	<.001	<.001	3	5
BRCA	NEK11 →	+0.935	+0.299	<.001	.008	3	5
BRCA	TTLL9 →	+0.971	+0.396	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035720 vs NPHP1 — LSCC

Explore this scatter interactively →