Intraciliary anterograde transport

Across TCGA cell cohorts, RNA activity of the Intraciliary anterograde transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHML, TNNI3K, and HMGB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary anterograde transport activity versus CHML in LARGE_INTESTINE (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHML →	+0.899	+0.663	<.001	<.001	3	5
PANCREAS	TNNI3K →	+0.454	+1.312	.001	<.001	3	4
KIDNEY	HMGB2 →	+1.128	+1.790	.008	<.001	3	4
BLOOD_Lymphoma	GCSAM →	+3.496	+1.112	.007	.002	3	4
OESOPHAGUS	BEGAIN →	-1.717	-0.996	.006	.006	3	4
LARGE_INTESTINE	KIF18A →	+1.060	+0.855	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035720 vs CHML — LARGE_INTESTINE

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