"CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPPL1, ARNT, and TFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INPPL1 grouped by "CD4-positive, alpha-beta T cell activation"-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INPPL1 →	-0.400	-1.592	.008	<.001	3	5
CNS	ARNT →	-0.312	-0.835	.005	.009	3	4
CNS	TFAP4 →	-0.164	-0.739	.004	.009	3	4
LARGE_INTESTINE	BAIAP2L1 →	+0.163	+0.975	.001	.003	3	4
STOMACH	MFN1 →	-0.203	-1.328	<.001	<.001	3	4
LIVER	USP10 →	-0.202	-1.194	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INPPL1 by "CD4-positive, alpha-beta T cell activation" activity — BONE

Explore this box plot interactively →