"CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCG, VMP1, and FADD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCG grouped by "CD4-positive, alpha-beta T cell activation"-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GCG →	+0.159	+0.283	.004	.002	3	4
LARGE_INTESTINE	VMP1 →	+0.664	+0.279	.004	.004	3	4
LUNG_SCLC	FADD →	+1.317	+0.225	.005	.001	2	5
BREAST	NPEPPS →	+0.961	+0.141	.001	<.001	3	4
BREAST	HLA-DRB1 →	+1.655	+0.142	.001	.001	3	4
SKIN	TM4SF18 →	+1.555	+0.217	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCG by "CD4-positive, alpha-beta T cell activation" activity — PANCREAS

Explore this box plot interactively →