"CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACSTD2, RGS8, and LPP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TACSTD2 grouped by "CD4-positive, alpha-beta T cell activation"-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TACSTD2 →	-0.128	-0.056	.004	.004	3	5
LUNG_SCLC	RGS8 →	+0.228	+0.150	.004	.009	3	5
LUNG_SCLC	LPP →	+0.263	+0.105	.003	<.001	3	5
LUNG_SCLC	EN2 →	+0.334	+0.127	.005	.005	2	5
BREAST	HCCS →	-0.297	-0.100	.005	<.001	3	4
LUNG_SCLC	CDK13 →	-0.288	-0.145	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TACSTD2 by "CD4-positive, alpha-beta T cell activation" activity — BLOOD_Myeloma

Explore this box plot interactively →