"CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, IL6ST, and TAP1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive, alpha-beta T cell activation" activity versus PSMB9 in LUNG_NSCLC_LUSC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PSMB9 →	+2.906	+0.125	<.001	<.001	3	16
LUNG_NSCLC_LUSC	IL6ST →	+1.969	+0.101	<.001	<.001	3	12
LUNG_SCLC	TAP1 →	+1.653	+0.083	.008	.004	3	11
LUNG_NSCLC_LUSC	CSF1 →	+2.526	+0.109	.003	<.001	3	11
STOMACH	IRF1 →	+1.451	+0.101	<.001	.001	3	11
LUNG_NSCLC_LUSC	VIM →	+5.911	+0.118	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035710 vs PSMB9 — LUNG_NSCLC_LUSC

Explore this scatter interactively →