"CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP29, POLK, and TTC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive, alpha-beta T cell activation" activity versus ARHGAP29 in LIVER (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ARHGAP29 →	-2.178	-0.331	.006	.003	3	7
URINARY_TRACT	POLK →	+1.088	+0.671	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TTC5 →	+1.062	+0.646	.002	.002	2	7
BLOOD_Lymphoma	NFIC →	+2.556	+0.244	<.001	<.001	3	6
BLOOD_Lymphoma	MPG →	+0.932	+0.282	.001	.006	3	5
URINARY_TRACT	EPCAM →	-4.242	-0.422	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035710 vs ARHGAP29 — LIVER

Explore this scatter interactively →