Hematopoietic stem cell migration

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM4, JAK3, and RASSF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell migration activity versus CEACAM4 in OV (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CEACAM4 →	+0.344	+0.674	.007	.001	3	4
BRCA	JAK3 →	+0.765	+0.334	<.001	<.001	3	4
BRCA	RASSF4 →	+0.565	+0.374	.003	<.001	3	4
GBM	LAIR1 →	+0.818	+0.565	.006	.002	3	4
GBM	FPR1 →	+0.933	+0.451	.002	.006	3	4
BRCA	CD163 →	+0.659	+0.307	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035701 vs CEACAM4 — OV

Explore this scatter interactively →