Hematopoietic stem cell migration

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, TICAM2, and TMEM255B, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell migration activity versus GAS6 in BLOOD_Myeloma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GAS6 →	+3.801	+1.397	<.001	<.001	3	17
LIVER	TICAM2 →	+2.140	+1.696	<.001	<.001	3	11
LIVER	TMEM255B →	+2.973	+1.988	<.001	<.001	3	9
LIVER	PDCD1LG2 →	+1.968	+1.574	<.001	<.001	3	9
LIVER	ZBTB38 →	+1.141	+1.306	.001	<.001	3	9
LUNG_NSCLC_LUSC	GPR176 →	+2.160	+0.984	.002	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035701 vs GAS6 — BLOOD_Myeloma

Explore this scatter interactively →