Monocyte extravasation

Across TCGA patient cohorts, RNA activity of the Monocyte extravasation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAP1, TEK, and CAVIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte extravasation activity versus DRAP1 in PDAC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DRAP1 →	-0.230	-0.210	.001	.007	3	4
GBM	TEK →	+0.720	+0.937	<.001	<.001	3	4
GBM	CAVIN2 →	+1.132	+0.931	<.001	<.001	3	4
GBM	LHFPL1 →	+0.804	+0.722	<.001	<.001	3	4
GBM	ACTG1 →	-0.436	-0.886	<.001	<.001	3	4
GBM	ERO1A →	-0.773	-0.790	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035696 vs DRAP1 — PDAC

Explore this scatter interactively →