Monocyte extravasation

Across TCGA cell cohorts, RNA activity of the Monocyte extravasation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASAP2, TTC7A, and AP1S1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASAP2 grouped by Monocyte extravasation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASAP2 →	+0.866	+1.005	.003	.003	3	4
OVARY	TTC7A →	+1.235	+1.349	.001	.001	3	4
OESOPHAGUS	AP1S1 →	-1.598	-1.649	.003	<.001	3	4
LUNG_NSCLC_LUSC	ZNF630 →	+1.246	+1.578	<.001	.001	3	4
OESOPHAGUS	EAPP →	+0.831	+1.444	.002	.002	3	4
CNS	THAP11 →	-0.322	-0.720	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASAP2 by Monocyte extravasation activity — OVARY

Explore this box plot interactively →