Monocyte extravasation

Across TCGA cell cohorts, RNA activity of the Monocyte extravasation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX9, HARS1, and ARHGEF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX9 grouped by Monocyte extravasation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DHX9 →	-0.441	-1.030	.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	HARS1 →	-0.134	-1.852	<.001	.004	3	5
LUNG_SCLC	ARHGEF3 →	-0.188	-1.471	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	LPAR3 →	-0.184	-1.779	.008	.002	3	4
STOMACH	FMR1NB →	+0.266	+1.596	.005	<.001	3	4
URINARY_TRACT	ITGAV →	+1.020	+2.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX9 by Monocyte extravasation activity — LUNG_SCLC

Explore this box plot interactively →