Monocyte extravasation

Across TCGA cell cohorts, RNA activity of the Monocyte extravasation pathway is significantly associated with the total protein of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are ETS-1, FRA1, and Mre11, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte extravasation activity versus ETS-1 in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ETS-1 →	+0.574	+0.357	.013	.023	3	1
BLOOD_Leukemia	FRA1 →	+1.101	+0.457	.007	.030	3	1
BLOOD_Leukemia	Mre11 →	-0.351	-0.367	.002	.022	3	1
BLOOD_Leukemia	Syk →	+1.572	+0.495	.013	.011	3	1
BLOOD_Leukemia	TTF1 →	+1.141	+0.344	.009	.028	3	1
BLOOD_Leukemia	Cyclin-D1 →	+0.371	+0.322	.008	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035696 vs ETS-1 — BLOOD_Leukemia

Explore this scatter interactively →