Monocyte extravasation

Across TCGA cell cohorts, RNA activity of the Monocyte extravasation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are VX-702, LMB_AB1, and Zoledronate, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VX-702 grouped by Monocyte extravasation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VX-702 →	-0.564	-0.293	.020	.025	3	1
BLOOD_Leukemia	LMB_AB1 →	+0.553	+0.325	.004	.049	3	1
BLOOD_Leukemia	Zoledronate →	+0.216	+0.306	.003	.038	3	1
BLOOD_Leukemia	Dacarbazine →	+0.356	+0.477	.003	.014	3	1
BLOOD_Leukemia	Voxtalisib →	+0.539	+0.239	.005	.028	3	1
BLOOD_Leukemia	GW-2580 →	+0.377	+0.216	.036	.032	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VX-702 by Monocyte extravasation activity — BLOOD_Leukemia

Explore this box plot interactively →