Mitochondrial protein catabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPATA18, DPCD, and FRAS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial protein catabolic process activity versus SPATA18 in UCEC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPATA18 →	+1.181	+0.065	<.001	<.001	3	4
LSCC	DPCD →	+0.455	+0.059	.004	.002	3	4
LSCC	FRAS1 →	+0.660	+0.070	<.001	<.001	3	4
LSCC	IGFBP2 →	+0.787	+0.068	<.001	<.001	3	4
LSCC	MLF1_S34 →	+0.851	+0.073	.001	<.001	3	4
LUAD	YWHAE →	+0.143	+0.048	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035694 vs SPATA18 — UCEC

Explore this scatter interactively →