Mitochondrial protein catabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSPH14, CKAP2L, and FAM72A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial protein catabolic process activity versus RSPH14 in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSPH14 →	+0.832	+0.968	.001	<.001	3	5
UCEC	CKAP2L →	-1.308	-1.381	<.001	<.001	3	5
UCEC	FAM72A →	-0.821	-1.262	<.001	<.001	3	5
UCEC	GTSE1 →	-1.122	-1.011	<.001	<.001	3	5
UCEC	LRRC23 →	+1.425	+0.973	<.001	<.001	3	5
UCEC	NME5 →	+0.984	+1.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035694 vs RSPH14 — UCEC

Explore this scatter interactively →