Oligopeptide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Oligopeptide transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOVA2, HTATIP2, and SAMSN1_S23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide transmembrane transport activity versus NOVA2 in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOVA2 →	-0.381	-0.028	<.001	.002	3	5
LSCC	HTATIP2 →	+0.468	+0.067	<.001	.003	3	5
UCEC	SAMSN1_S23 →	+0.551	+0.062	<.001	.001	3	5
CCRCC	SKAP2 →	+0.308	+0.043	.003	.006	3	5
COAD	NCF2 →	+0.434	+0.048	<.001	<.001	3	5
CCRCC	PKP3_S180 →	+2.016	+0.065	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035672 vs NOVA2 — BRCA

Explore this scatter interactively →