Oligopeptide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Oligopeptide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADM3-AS1, EXOC3L4, and SLC7A11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide transmembrane transport activity versus CADM3-AS1 in LUAD (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CADM3-AS1 →	-0.267	-0.467	.001	<.001	3	4
CCRCC	EXOC3L4 →	-0.547	-0.430	.002	.005	3	4
HNSC	SLC7A11 →	+1.460	+0.895	<.001	<.001	3	3
CCRCC	EIF3LP2 →	-0.380	-0.541	.001	<.001	3	3
LUAD	SLC14A1 →	-0.242	-0.409	.008	.003	3	3
LUAD	PGAM1 →	+0.281	+0.286	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035672 vs CADM3-AS1 — LUAD

Explore this scatter interactively →