Oligopeptide transmembrane transport

Across TCGA cell cohorts, RNA activity of the Oligopeptide transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5P3, UBE2DNL, and NDUFAB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FABP5P3 grouped by Oligopeptide transmembrane transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FABP5P3 →	+0.187	+1.111	.002	.005	3	3
SKIN	UBE2DNL →	+0.337	+0.422	.006	.005	3	3
UPPER_AERODIGESTIVE_TRACT	NDUFAB1 →	+0.534	+1.836	.008	<.001	3	3
KIDNEY	SCO1 →	+0.279	+2.212	.006	<.001	3	3
PANCREAS	AHI1 →	+0.172	+1.760	.003	<.001	3	3
SKIN	GMCL1 →	+0.165	+0.363	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FABP5P3 by Oligopeptide transmembrane transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →